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KMID : 1145520190050010003
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Journal of Radiopharmaceuticals and Molecular Probes
2019 Volume.5 No. 1 p.3 ~ p.10
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The development of a portable MO4-(M = 188Re or 99mTc) concentration device for extending the lifetime of RI generators
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Choi Kang-Hyuk
Kim Jong-Bum
Jang Beom-Su
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Abstract
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The activities per volume of 188Re and 99mTc from their generators are dependent on the specific activity of their mother nuclides 188W and 99Mo respectively. After a particular lapse of time, the eluted RI activity is exponentially reduced and thus cannot satisfy the needs of clinical application. The purpose of this study is to develop a 188Re and 99mTc concentration device with a compact size that can extend the period of use as well as conveniently concentrate the RI. We designed the concentration module by including two-different check valves that do not required any manual on-off operations. In these concentration process, cation exchange resin embedded with Ag and anion exchange resins were used. After completing the concentrating step, the recovering yield was identified to be more than 93% for 188Re generators and 88% for 99mTc generators. Moreover, all these procedures were done within 5 min.
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KEYWORD
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RI concentration, Concentration device, Technetium-99m (Tc-99m), Rhenium-188 (Re-188), Validity period
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